Heart attack modeled with human stem cells


Release Subtitle: Toward the development of individual model of ischemic heart disease

Release Summary Text:
•A model of ischemic heart disease was developed using human induced pluripotent stem cells (hiPSC).
•This model can provide a useful platform for developing effective drugs without sacrificing animals.

Full text of release:
Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated from human induced pluripotent stem cells.

The journal Biochemical and Biophysical Research Communications published the study, with Ken Takahashi, Ph.D., as corresponding author, and Wei Heng, MSc., a graduate student in the Naruse Lab, as first author.

To date, laboratory animals such as mouse have been used to model diseases including myocardial infarction. However, there have been concerns about difference in characteristics of cardiomyocytes e.g. heart rate and action of drugs, based on the difference of gene expression between laboratory animals and human.

“This myocardial infarction model will contribute to the development of preventive/therapeutic medicine more effective to human even without sacrificing animals,” said Ken Takahashi, Ph.D., assistant professor in the university and lead author of the study.


Contact Person: TAKAHASHI Ken

Contact: E-mail: takah-k2(a) okayama-u.ac.jp
For inquiries, please contact us by replacing (a) with the @ mark.

Microscopic picture of cardiomyocytes differentiated from human induced pluripotent stem cells. Green indicates cardiac troponin protein, showing typical striated pattern. Red: actin protein. Blue: cellular nucleus.