"Family bonds bring treatment potential" was introduced in the article of Nature Index

January.23.2018RESEARCH HIGHLIGHTS

Iridium-catalysed hydrosilylation of cyclopropanes via regioselective carbon–carbon bond cleavage

Journal: Chemical Communications

Published: 2017-08-15

DOI: 10.1039/c7cc04296e

Affiliations: 2

Authors: 5

Research Highlight

Family bonds bring treatment potential

An iridium catalyst that selectively attaches silicon atoms to organic molecules could allow for the discovery of novel therapeutic drugs.

Silicon and carbon are chemical siblings. Found in the same family on the periodic table, the two are chemically and physically similar, but not identical. Adding silicon to a carbon-based drug molecule can fine-tune the molecule’s behaviour in the body and potentially improve its therapeutic effect.

Masahito Murai, Kazuhiko Takai and their colleagues at Okayama University have now discovered a versatile way to attach triethylsilane, a silicon-containing compound, to carbon-based organic molecules. Using an iridium complex as a catalyst, the team was able to use triethylsilane to spring open a three-carbon ring called a cyclopropane. The silicon group becomes attached to the ring-opened molecule as part of the reaction.

The diversity of cyclopropane-containing molecules the reaction worked with suggests it could be a versatile way to incorporate silicon into molecules with useful medicinal properties.

Supported content

1.Chemical Communications 53, 9281–9284 (2017). doi: 10.1039/c7cc04296e

Institutions

Division of Applied Chemistry, Okayama University, Japan

research Institute for Interdisciplinary Science(RIIS), Okayama University, Japan

 

 

 

 

 

 

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